Autophagy is required for zebrafish caudal fin regeneration
نویسندگان
چکیده
منابع مشابه
Hyaluronic acid synthesis is required for zebrafish tail fin regeneration
Using genome-wide transcriptional profiling and whole-mount expression analyses of zebrafish larvae, we have identified hyaluronan synthase 3 (has3) as an upregulated gene during caudal fin regeneration. has3 expression is induced in the wound epithelium within hours after tail amputation, and its onset and maintenance requires fibroblast growth factor, phosphoinositide 3-kinase, and transformi...
متن کاملActivin-betaA signaling is required for zebrafish fin regeneration.
Vertebrate limb regeneration occurs in anamniotes such as newts, salamanders, and zebrafish. After appendage amputation, the resection site is covered by a wound epidermis capping the underlying mature tissues of the stump from which the blastema emerges. The blastema is a mass of progenitor cells that constitute an apical growth zone. During outgrowth formation, the proximal blastemal cells pr...
متن کاملActivin-βA Signaling Is Required for Zebrafish Fin Regeneration
Vertebrate limb regeneration occurs in anamniotes such as newts, salamanders, and zebrafish [1–4]. After appendage amputation, the resection site is covered by a wound epidermis capping the underlying mature tissues of the stump from which the blastema emerges. The blastema is a mass of progenitor cells that constitute an apical growth zone. During outgrowth formation, the proximal blastemal ce...
متن کامل19-P025 Bone dynamics during adult zebrafish caudal fin regeneration
Planaria possess a population of pluripotent adult stem cells called neoblasts, capable of differentiating into all cell types required to regenerate entire animals from almost any fragment. The regeneration of different fragments is catalogued in a body of classical experiments by many eminent scientists. Here, we endeavour to explore these classical observations and insights and combine them ...
متن کامل2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits zebrafish caudal fin regeneration.
Adult zebrafish completely regenerate their caudal fins following partial amputation. Fin regrowth can easily be monitored in vivo and regenerating tissues can be used to study this dynamic developmental process. In this study we determined that fin regeneration is significantly affected by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Zebrafish caudal fins were partially amputated, a...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2013
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2013.175